Aerobic glycolysis, motility, and cytoskeletal remodeling
نویسندگان
چکیده
The James Buchanan Brady Urological Institute and Department of Urology; Johns Hopkins School of Medicine; Baltimore, MD USA; The James Buchanan Brady Urological Institute and Department of Oncology; Johns Hopkins School of Medicine; Baltimore, MD USA; The James Buchanan Brady Urological Institute and Department of Pharmacology and Molecular Science; Johns Hopkins School of Medicine; Baltimore; MD USA; Department of Chemical and Biomolecular Engineering; Johns Hopkins University; Baltimore, MD USA
منابع مشابه
Glycolysis is the primary bioenergetic pathway for cell motility and cytoskeletal remodeling in human prostate and breast cancer cells
The ability of a cancer cell to detach from the primary tumor and move to distant sites is fundamental to a lethal cancer phenotype. Metabolic transformations are associated with highly motile aggressive cellular phenotypes in tumor progression. Here, we report that cancer cell motility requires increased utilization of the glycolytic pathway. Mesenchymal cancer cells exhibited higher aerobic g...
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Instead of relying on mitochondrial oxidative phosphorylation, most cancer cells rely heavily on aerobic glycolysis, a phenomenon termed as "the Warburg effect". We considered that this effect is a direct consequence of damage which persists in cancer cells that recover from damage. To this end, we studied glycolysis and rate of cell proliferation in cancer cells that recovered from severe dama...
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The cytoskeleton is a network of interconnected protein filaments, which provide a three-dimensional scaffold for cells. Remodeling of the cytoskeleton is important for key cellular processes, such as cell motility, division, or morphogenesis. This remodeling is traditionally considered to be driven exclusively by processes consuming chemical energy, such as the dynamics of the filaments or the...
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